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PDE4 inhibition suppresses IL-17-associated immunity in dry

Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA.PURPOSE: To determine the effect of phosphodiesterase type-4 (PDE4)

4(4-ALKOXY-3-HYDROXYPHENYL)-2-PYRROLIDONE DERIVATIVES AS PDE-

A61K31/4015; C07D207/267; A61P9/10; A61P25/00; A61P25/14; A61P25/16; A61P25/24; A61P25/28; A61P29/00; A61P31/16; A61P37/08;

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DRUG COMBINATIONS CONTAINING PDE4 INHIBITORS AND NSAIDS -

2. A drug combination comprising a PDE4 inhibitor of formula 1 wherein: 14. The drug combination according to claim 12, wherein: R3 is

PDE4 inhibition suppresses IL-17-associated immunity in dry

Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA.PURPOSE: To determine the effect of phosphodiesterase type-4 (PDE4)

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The glucose-lowering effects of the PDE4 inhibitors

Aims/hypothesis The cAMP-degrading phosphodiesterase 4 (PDE4) enzyme has recently been implicated in the regulation of glucagon-like peptide-1 (

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DISC1、PDE4-

Initial improvements in difficult-to-treat forms of psoriasis persisted for a year with the phosphodiesterase 4 (PDE4) inhibitor apremilast (Otezla, Celgene

Combinations of medicaments, containing PDE4-inhibitors and

1. A medicament comprising an EP4 receptor antagonist and a PDE4 14. The medicament according to claim 12, wherein: R3 is a monocyclic

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the Discovery of New type 4 cAMP Phosphodiesterase (PDE4)

PDF | Type 4 cAMP phosphodiesterase (PDE4) inhibitors show a broad spectrum of anti-inflammatory effects in almost all kinds of inflamed cells, by an

Ether derivatives useful as inhibitors of PDE4 isozymes -

which are useful as inhibitors of PDE4 in the EP0550900 1993-07-14 Herbicidal and plant-Resp. J., 12 (Suppl. 28), 362s, 1998, P

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28-7 | 801315-14-0 | 1415560-64-3 | PDE4 ionhibitor | MedKoo

GSK256066 is a potent and selective PDE4 inhibitor that can be given by inhalation, minimising the potential for side effects. GSK256066 demonstrated a

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of (14) C- and (2) H-labelled CHF6001 a new potent PDE4

Abstract: A eight steps preparation of (14) C-labelled CHF6001, a potent PDE4 inhibitor in the treatment of respiratory diseases, is described. An

Oxazolyl-acid amide derivatives useful as inhibitors of PDE4

This application is directed to compounds useful as inhibitors of PDE4 in A61P25/14; A61P25/16; A61P25/24; A61P25/28; A61P27/02; A6

BIARYL PDE4 INHIBITORS FOR TREATING PULMONARY AND

2009528-15. A compound or salt according to claim 14 28. A salt of a compound of claim 1 wherein SUBSTITUTED BENZOAZOLE PDE4 INHIBITORS FOR

Pharmacokinetic/Pharmacodynamic Modeling of the PDE4

PDE4 inhibitors have primarily been investigated in inflammatory HbA1c levels on days -1, 14, and 28 from vehicle and treatment

NICOTINAMIDE DERIVATIVES USEFUL AS PDE4 INHIBITORS - Pfizer

A61P37/00; A61P37/08; C07D409/14; C07D413/14; C07D417/14; C07DBENZOFUSED-HETEROCYCLYL DERIVATIVES USEFUL AS SELECTIVE INHIBITORS OF PDE4

Biaryl PDE4 inhibitors for treating inflammatory,

The present invention relates to a genus of biaryl compounds containing at least one further ring. The compounds are PDE4 inhibitors useful for the

Pyridazin-3(2 H )-One Derivatives and Their Use as PDE4

ALEXANDRIA, Va., June 17 -- United States Patent no. 7,960,383, issued on June 14, was assigned | Article from US Fed News

Specific Cyclic Nucleotide Phosphodiesterase Type 4 (PDE4)

2012111-PDE4 activity levels in the kidneys of 18 week-old MRL/lpr lupus-(14.4 nM), PDE4A-IC50 (44 nM) and PDE4B-IC50 (48 nM) (

amide derivatives useful as inhibitors of PDE4 isozymes -

This application is directed to compounds useful as inhibitors of PDE4 in the treatment of diseases regulated by the activation and degranulation of

the Activity of the cAMP-specific Phosphodiesterase PDE4A5

kinase to phosphorylate PDE4A5 in intact cells. such as cyclosporin, FK506, or rapamycin (14).have used extensively in the past (6, 23, 28